Tony Truran

Lecturer/Technical Assistant

at Williams July 1996-June 1999, August 2002-present

Education

University of Massachusetts Amherst, B.S. (Biochemistry), 1989
University of Massachusetts, M.S. (Chemistry), 1992
University of Massachusetts, Ph.D.(Chemistry), 1998 (Advisor: Louis A. Carpino)
Advantage of the Highly Base-Sensitive Benzo(b)thiophenesulphone-2-methoxycarbonyl Amino-Protecting Group for the Assembly of peptides Subject to Base-Catalyzed Side Reactions

Contact Information

Office: Thompson Chemistry Lab 213
Telephone: (413) 597-3318
E-mail: George.A.Truran@williams.edu

Laboratory Courses Taught

CHEM 156: Organic Chemistry: Introductory Level
CHEM 251: Organic Chemistry: Intermediate Level

Publications

Carpino, L. A., El-Faham, A., Truran, G. A., Triolo, S. A., Shroff, H., Griffin, G. W., Minor, C. A., Kates, S. A., Albericio, F. Azabenzotriazole-based coupling reagents in solid-phase peptide synthesis. Peptides: Chemistry, Structure, and Biology., Proc. Am. Pept. Symp., 13th, pp.124-126 (1994).
Carpino, Louis A., El-Faham, Ayman, Truran, George A., Minor, Charles A., Kates, Steven A., Griffin, G. William, Shroff, Hitesh, Triolo, Salvatore A., Albericio, Fernando. New approaches for extending the scope of solid-phase peptide synthesis. Innovation Perspect. Solid Phase Synth. Collect. Pap., Int. Symp., 3rd , pp.95-104 (1994).
Granitza, Doerthe, Beyermann, Michael, Wenschuh, Holger, Haber, Hanka, Carpino, Louis A., Truran, George A., Bienert, Michael. Efficient Acylation of Hydroxy Functions by Means of Fmoc Amino Acid Fluorides. J. Chem. Soc., Chem. Commun., 2223, (1995).
Carpino, Louis A., Chao, Hann Guang, Ghassemi, Shahnaz, Mansour, E. M. E., Riemer, Christoph, Warrass, Ralf, Sadat-Aalaee, Dean, Truran, George A., Imazumi, Hideko. Novel Carboxylic Acid and Carboxamide Protective Groups Based on the Exceptional Stabilization of the Cyclopropylmethyl Cation. J. Org. Chem., 60, 7718, (1995).
Wenschuh, Holger, Beyermann, Michael, Granitza, Doerthe, Haber, Hanka, Truran, George A., Bienert, Michael, Carpino, Louis A. Amino acid fluorides in peptide synthesis-efficient acylation of hydroxyl functions and extension of the method to very bulky amino acid residues. Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries: Peptides, Proteins and Nucleic Acids--Small Molecule Organic Chemical Diversity, Collected Papers, International Symposium, 4th, Edinburgh, Sept. 12-16, pp. 131-134, (1996).
Carpino, Louis A., Philbin, Michael, Ismail, Mohamed, Truran, George A., Mansour, E. M. E., Iguchi, Shin, Ionescu, Dumitru, El-Faham, Ayman, Riemer, Christoph, Warrass, Ralf, Weiss, Manfred S. A New Family of Base- and Nucleophile-Sensitive Amino-Protecting Groups. A Michael-Acceptor Based Deblocking Process. Practical Utilization of the Benzo[b]thiophenesulfone-2-methoxycarbonyl (Bsmoc) Group. J. Am. Chem. Soc., 119, 9915 (1997).
Carpino, Louis A., Ismail, Mohamed, Truran, George A., Mansour, E. M. E., Iguchi, Shin, Ionescu, Dumitru, El-Faham, Ayman, Riemer, Christoph, Warrass, Ralf. The 1,1-Dioxobenzo[b]thiophene-2-ylmethoxycarbonyl (Bsmoc) Amino-Protecting Group. J. Org. Chem., 64, 4324 (1999).
Truran, George A., Aiken, Karelle S., Fleming, Thomas R., Webb, Peter J., Markgraf, J. Hodge. Solid Phase Organic Synthesis and Combinatorial Chemistry; A Laboratory Preparation of Oligopeptides. J. Chem. Ed., 79, 85 (2002).
Carpino, Louis A., Ghassemi, Shahnaz, Ionescu, Dumitru, Ismail, Mohamed, Sadat-Aalaee, Dean, Truran, George A., Mansour, E. M. E., Siwruk, Gary A., Eynon, John S., Morgan, Barry. Rapid, Continuous Solution-Phase Peptide Synthesis: Application to Peptides of Pharmaceutical Interest. Organic Process Research & Development, 7(1), 28, (2003).

Research Interests

Research interests include: orthogonal protection schemes for organic synthesis, improved methods of acylation reactions (e.g., coupling reagents, acyl halides, nucleophilic catalysis), and solid phase and solution peptide synthesis. The application of aforementioned to the synthesis of: "difficult peptide sequences", non-proteogenic peptide analogs, and a new classes of peptide based compounds which act as "molecular scissors".

Williams Chemistry