This course focuses on the application of physicochemical theoretical methods to biophysical and biochemical systems. The basis of the classical theoretical models, as well as new theoretical approaches to biological phenomena are discussed. The predictions of these theoretical models are compared to the results obtained by experiment. The topics include a thermodynamic approach to biochemical reactions and bioenergetics; receptor-mediated endocytosis; nonequilibrium kinetics of concentrated enzyme solutions; analysis of the differences between direct transfer and diffusional transfer of metabolites; and mathematical immunology, with an emphasis on the complement system. After an initial meeting of all students, groups of two students meet with the instructor weekly for fifty minutes where one student gives an oral presentation. Both students are responsible for readings and written solutions to assigned problems based on advanced-level textbooks, review articles, and research journals. The last week is devoted to the presentation of final projects. Format: tutorial. Evaluation will be based on the quality of presentations, class participation, written essays, solutions to problems, and an oral final exam. Prerequisites: Chemistry 366 or 367 and a basic knowledge of applied mathematics as provided by Mathematics 210 and 211 and permission of instructor. Enrollment limit: 8 (expected: 5).