This course provides the student an understanding of the applicability of current laboratory instrumentation both to the elucidation of fundamental chemical phenomena and to the measurement of certain atomic and molecular parameters. Experimental methods, including absorption and emission spectroscopy in the x-ray, ultraviolet, visible, infrared, microwave, and radio frequency regions, chromatography, electrochemistry, mass spectrometry, magnetic resonance, and thermal methods are discussed, with examples drawn from the current literature. The analytical chemical techniques developed in this course are useful in a wide variety of scientific areas. The course also covers new developments in instrumental methods and advances in the approaches used to address modern analytical questions. Format: lectures, three hours a week; laboratory, four hours a week. Evaluation is based on problem sets, laboratory work, exams, and an independent project. Prerequisites: Chemistry 201-202, or Chemistry 155 and 251/255. May be taken concurrently with Chemistry 256 with permission of instructor. No enrollment limit (expected: 15).