This course explores the structure and function of prokaryotic and eukaryotic genes using an integrated genetic and molecular approach. Topics include: transcriptional and post-transcriptional regulation, DNA replication and repair, chromatin structure, transposable genetic elements, and genomics. A central feature of the course will be discussion of articles from the primary literature, with an emphasis on the genetic bases for a variety of cellular pathologies. Laboratory will consist of a semester-long project that incorporates site-directed mutagenesis, cloning, southern hybridization, and polymerase chain reaction. Format: lectures/discussion/laboratory, six hours a week. Evaluation will be based on periodic exams, lab reports, class presentation, and a grant proposal. Prerequisite: Biology 202. Enrollment limit: 32 (expected: 24). Preference to senior and then to junior Biology majors. This is a quantitative/formal reasoning course.