Genomics, the study of complete DNA sequences of organisms, has been touted as the new revolution in biology. Yet at this early stage of the field, a limited amount of new biology has been revealed through experimental and analytical manipulations of genomic information. This tutorial course, aimed primarily at sophomores, explores the extent to which genomics research has, and has not, expanded our understanding of biology. We begin by understanding the experimental means of acquiring correct and complete DNA sequence(s) of a species. This background allows a critical analysis of the current data and databases used in genomic analysis. Reading recent primary literature, we will then fully examine experimental approaches that assess interesting biological phenomena on a genome-wide basis. For example, we will study papers describing the genome-wide changes in messenger RNA levels when a pathogen infects a host, or when fruit flies proceed through a normal twenty-four hour cycle, in order to assess how these experiments enlighten our understanding of particular biological systems. The course will also explore topics in proteomics, the study of complete protein sequences obtained from genomics analysis. The quest for understanding the diversity and evolution of a protein family, for discovering a minimal genome capable of life, or for predicting the precise molecular functions of proteins based on comparative genomic analyses are potential proteomics issues to be analyzed. The class will meet as a whole once per week to discuss and refine questions on required readings of primary literature. Each student will also be assigned to a weekly tutorial meeting with the instructor and one other student. Every other week at this tutorial meeting, students will present a written and oral critical analysis of the assigned reading. Students not making a presentation will question and critique the work of their colleague. Format: discussion 75 minutes a week, tutorial meeting 1 hour a week. Evaluation will be based on discussion participation, tutorial participation, and five tutorial papers of four pages each. Prerequisite: Biology 202. Enrollment limit: 10 (expected: 10). Preference given to sophomores. This course is writing intensive.