This discussion-based course is an advanced physiology course that examines mammalian organ function at the molecular level. Important proteins and biochemical events that dictate subcellular and cellular processes will be discussed for many organ systems. Material will be presented and discussed in the context of the molecular basis of pathophysiological states of human disease. Topics will include numerous genetic predispositions and diseases including Type II diabetes, hypertension, and obesity. Lectures (once per week) will be derived from textbooks and original literature. Student-led discussions (twice per week) will come from the original literature. Format: lectures/discussions, three hours a week. Evaluation will be based on hourly exams, short papers, and a final exam. Prerequisite: Biology 202, 205 or permission of instructor. Enrollment limit: 40 (expected: 20). Preference given to Biology majors. Satisfies distribution requirement in major.