What does statistics have to do with designing and carrying out experiments? The answer is, surprisingly perhaps, a great deal. In this course, we will study how to design an experiment in order to obtain the most information from it in the fewest number of observations. The efficient design of experiments is important not only in the sciences: it has been credited for helping Japanese industry achieve its success. The examples from this course will be primarily from the physical sciences and industry, but will apply to the biological and to some extent the social sciences as well. The culmination of the course will be a project where each student designs, carries out, analyzes, and presents an experiment of interest to him or her. Evaluation will be based primarily on performance on the project, homework, and exams. Prerequisite: some knowledge of statistics or permission of instructor.